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Tag kinase [272 articles]

Recent papers classified by the tag kinase.
  • Analysis of yeast protein kinases using protein chips.
    Nat Genet, Vol. 26, No. 3. (November 2000), pp. 283-289.
    by H Zhu, JF Klemic, S Chang, P Bertone, A Casamayor, KG Klemic, D Smith, M Gerstein, MA Reed, M Snyder
    posted to chip kinase method by Yanno on 2006-05-28 17:04:29 as read
  • Protein Kinase Inhibitors: Insights into Drug Design from Structure
    Science, Vol. 303, No. 5665. (19 March 2004), pp. 1800-1805.
    by Martin E Noble, Jane A Endicott, Louise N Johnson
    posted to chemical inhibitor kinase review by Yanno on 2006-05-28 16:51:18 as read along with 4 people superpyrin tjimenez aqeel kummerj
  • A small molecule–kinase interaction map for clinical kinase inhibitors
    Nature Biotechnology, Vol. 23, No. 3. (13 February 2005), pp. 329-336.
    by Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne M Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart
    posted to chemical drugdiscovery inhibitor kinase by Yanno on 2006-05-28 16:40:13 as read along with 6 people hchmani BragilMassoud tjimenez kuhn 7ofAnn seowu
  • The protein kinase complement of the human genome.
    Science, Vol. 298, No. 5600. (6 December 2002), pp. 1912-1934.
    by G Manning, DB Whyte, R Martinez, T Hunter, S Sudarsanam
    posted to datamining functionnalgenomics kinase by Yanno on 2006-05-28 16:38:24 as read along with 7 people daed Evangelia ceolas tjimenez kuhn aqeel lenov
  • Toward a pharmacophore for kinase frequent hitters.
    J Med Chem, Vol. 47, No. 23. (4 November 2004), pp. 5616-5619.
    by AM Aronov, MA Murcko
    posted to chemical kinase by Yanno on 2006-05-28 16:37:28 as read along with 1 person BragilMassoud
  • Genome-wide survey of protein kinases required for cell cycle progression
    Nature, Vol. 432, No. 7020. (23 December 2004), pp. 980-987.
    by M Bettencourt-Dias, R Giet, R Sinka, A Mazumdar, WG Lock, F Balloux, PJ Zafiropoulos, S Yamaguchi, S Winter, RW Carthew, M Cooper, D Jones, L Frenz, DM Glover
    posted to kinase by Yanno on 2006-05-28 16:35:32 as read
  • Features of selective kinase inhibitors.
    Chem Biol, Vol. 12, No. 6. (June 2005), pp. 621-637.
    by ZA Knight, KM Shokat
    posted to chemical drugdiscovery inhibitor kinase review by Yanno on 2006-05-28 16:33:09 as read along with 3 people seancutler anwazo pjasper
  • Tyrosine kinase inhibitors: a new approach for asthma
    Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, Vol. 1697, No. 1-2. (11 March 2004), pp. 53-69.
    by Fred WS Wong, Khai P Leong
    posted to disease inhibitor kinase by Yanno on 2006-05-28 16:30:58 as read
  • Gini Coefficient: A New Way To Express Selectivity of Kinase Inhibitors against a Family of Kinases
    J. Med. Chem., Vol. 50, No. 23. (15 November 2007), pp. 5773-5779.
    by PP Graczyk
    posted to kinase method proteomics statistics by Yanno on 2008-01-04 17:46:05 as read along with 1 person daevans
  • notes Targeting Tyrosine Kinases in Cancer: The Second Wave
    Science, Vol. 312, No. 5777. (26 May 2006), pp. 1175-1178.
    by Jose Baselga
    posted to disease inhibitor kinase review by Yanno on 2006-05-30 08:41:14 as read
  • Mechanism-based profiling of enzyme families.
    Chem Rev, Vol. 106, No. 8. (August 2006), pp. 3279-3301.
    by MJ Evans, BF Cravatt
    posted to kinase protease review targetbeads usp by Yanno on 2007-10-30 16:54:11 as read
  • High-throughput kinase assays with protein substrates using fluorescent polymer superquenching.
    BMC Biotechnol, Vol. 5, No. 1. (31 May 2005)
    by F Rininsland, C Stankewicz, W Weatherford, D McBranch
    posted to assay fluorescent kinase method by Yanno on 2006-01-27 13:47:26 as read
  • Functional interrogation of the kinome using nucleotide acyl phosphates.
    Biochemistry, Vol. 46, No. 2. (16 January 2007), pp. 350-358.
    by MP Patricelli, AK Szardenings, M Liyanage, TK Nomanbhoy, M Wu, H Weissig, A Aban, D Chun, S Tanner, JW Kozarich
    posted to kinase method proteomics targetbeads by Yanno on 2007-11-12 12:21:06 as read
  • Allosteric inhibitors of Bcr-abl-dependent cell proliferation
    Nat Chem Biol, Vol. 2, No. 2. (February 2006), pp. 95-102.
    by Francisco J Adrian, Qiang Ding, Taebo Sim, Anastasia Velentza, Christine Sloan, Yi Liu, Guobao Zhang, Wooyoung Hur, Sheng Ding, Paul Manley, Jurgen Mestan, Doriano Fabbro, Nathanael S Gray
    posted to inhibitor kinase by Yanno on 2006-06-19 13:48:43 as read
  • High-throughput kinase profiling as a platform for drug discovery
    Nat Rev Drug Discov, Vol. 7, No. 5. (May 2008), pp. 391-397.
    by David M Goldstein, Nathanael S Gray, Patrick P Zarrinkar
    posted to review kinase hts hcs drugdiscovery by Yanno on 2008-05-16 14:48:27 as read along with 3 people superpyrin oelemento renatomilani
  • A quantitative analysis of kinase inhibitor selectivity
    Nature Biotechnology, Vol. 26, No. 1. (08 January 2008), pp. 127-132.
    by Mazen W Karaman, Sanna Herrgard, Daniel K Treiber, Paul Gallant, Corey E Atteridge, Brian T Campbell, Katrina W Chan, Pietro Ciceri, Mindy I Davis, Philip T Edeen, Raffaella Faraoni, Mark Floyd, Jeremy P Hunt, Daniel J Lockhart, Zdravko V Milanov, Michael J Morrison, Gabriel Pallares, Hitesh K Patel, Stephanie Pritchard, Lisa M Wodicka, Patrick P Zarrinkar
    posted to assay chemogenomics drugdiscovery inhibitor kinase quantification by Yanno on 2008-01-22 09:20:37 as read along with 5 people hchmani jyuh tmmurali psique renatomilani
  • PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
    Nature Reviews Drug Discovery, Vol. 5, No. 11. (13 October 2006), pp. 903-918.
    by Thomas Rückle, Matthias K Schwarz, Christian Rommel
    posted to drugdiscovery inflammation kinase review target by Yanno on 2006-11-27 15:03:34 as read along with 1 person jyuh
  • Pharmacological inhibitors of cyclin-dependent kinases.
    Trends Pharmacol Sci, Vol. 23, No. 9. (September 2002), pp. 417-425.
    by M Knockaert, P Greengard, L Meijer
    posted to cdk cell cycle cyclin inhibitor kinase pharmacology small transcription by xico on 2007-02-13 01:44:23 as ** along with 1 group WetBiology
  • Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1.
    J Biol Chem (19 December 2005)
    by Jia-Lin L Ma, Soo-Jung J Lee, Jimmy K K Duong, David F F Stern
    posted to checkpoint kinase mec1 rad53 by xico on 2006-01-24 20:33:12 as ** along with 1 person and 1 group tuck WetBiology
  • A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs.
    Biochem Biophys Res Commun, Vol. 279, No. 3. (29 December 2000), pp. 832-837.
    by F Marquès, Et Al
    posted to 5 cdc2-like cdc2-related cdc2l5 cdk cdk13 cell ctd cycl cycle cyclinl development early kinase motif mrna novel pitaivre rnapolii sea splicing sr subfamily synthesis urchin by xico on 2007-05-18 01:46:26 as read along with 1 group WetBiology
  • Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.
    Mol Cell Biol, Vol. 26, No. 3. (February 2006), pp. 777-788.
    by Y Pei, H Du, J Singer, C Stamour, S Granitto, S Shuman, RP Fisher
    posted to cap cdk-activating cdk9 cks1 fission kinase mcs6 methytransferase pcm1 tfiih yeast by xico on 2006-02-05 00:37:38 as *** along with 1 group WetBiology
  • The RNA polymerase II CTD kinase Ctk1 functions in translation elongation.
    Genes Dev, Vol. 21, No. 11. (1 June 2007), pp. 1409-1421.
    by Susanne Röther, Katja Sträßer
    posted to ctd ctd-cdk ctk1 elongation ii kinase polymerase rna rnapii translation by xico on 2007-06-06 16:15:51 as ***** along with 1 group WetBiology
  • ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos
    Development, Vol. 132, No. 3. (1 February 2005), pp. 579-589.
    by Rada Philipova, Jolanta Kisielewska, Pin Lu, Mark Larman, Jun-Yong Huang, Michael Whitaker
    posted to ca2 calcium cdk1 cdk2 development dna early embryogenesis erk1 fertilization influx kinase mapk onset replication s-phase sea urchin by xico on 2007-06-27 21:13:12 as ** along with 1 group WetBiology
  • Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
    J Biol Chem, Vol. 279, No. 6. (6 February 2004), pp. 4612-4624.
    by K de Graaf, P Hekerman, O Spelten, A Herrmann, LC Packman, K Büssow, G Müller-Newen, W Becker
    posted to cyclin dyrk1a kinase splicing substrate by WBecker on 2006-07-04 12:36:16 as read
  • Description of an IL-1-responsive kinase that phosphorylates the K protein. Enhancement of phosphorylation by selective DNA and RNA motifs.
    Biochemistry, Vol. 34, No. 16. (25 April 1995), pp. 5644-5650.
    by I Van Seuningen, J Ostrowski, K Bomsztyk
    posted to antibody hnrnpk kinase by uz_labu_laimi on 2007-04-10 15:04:41 as **
  • Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
    Cell, Vol. 112, No. 6. (21 March 2003), pp. 859-871.
    by Bhushan Nagar, Oliver Hantschel, Matthew A Young, Klaus Scheffzek, Darren Veach, William Bornmann, Bayard Clarkson, Giulio Superti-Furga, John Kuriyan
    posted to kinase structure1opk by tny on 2006-04-21 03:29:01 as ** along with 1 person brseavey
  • Structural Basis for Domain-Domain Communication in a Protein Tyrosine Kinase, the C-terminal Src Kinase
    Journal of Molecular Biology, Vol. In Press, Corrected Proof
    by Xiaofeng Lin, Yuehao Wang, Yousef Ahmadibeni, Keykavous Parang, Gongqin Sun
    posted to domain_interaction enzyme kinase by tny on 2006-02-21 05:54:41 as **
  • The Conformational Plasticity of Protein Kinases
    Cell, Vol. 109, No. 3. (3 May 2002), pp. 275-282.
    by Morgan Huse, John Kuriyan
    posted to enzyme kinase plasticity review by tny on 2007-02-14 12:53:45 as **
  • Structure of the carboxyl-terminal Src kinase, Csk.
    J Biol Chem, Vol. 277, No. 17. (26 April 2002), pp. 14351-14354.
    by A Ogawa, Y Takayama, H Sakai, KT Chong, S Takeuchi, A Nakagawa, S Nada, M Okada, T Tsukihara
    posted to kinase by tjimenez on 2007-02-07 08:16:18 as **
  • Functional Classification of Protein Kinase Binding Sites Using Cavbase.
    ChemMedChem, Vol. 2, No. 10. (8 October 2007), pp. 1432-1447.
    by Daniel Kuhn, Nils Weskamp, Eyke Hüllermeier, Gerhard Klebe
    posted to kinase by tjimenez on 2007-10-24 13:01:12 as **
  • Information decay in molecular docking screens against holo, apo, and modeled conformations of enzymes.
    J Med Chem, Vol. 46, No. 14. (3 July 2003), pp. 2895-2907.
    by SL McGovern, BK Shoichet
    posted to kinase by tjimenez on 2007-01-15 16:54:27 as ** along with 2 people dgruiz blackbart
  • Rapid computational identification of the targets of protein kinase inhibitors.
    J Med Chem, Vol. 48, No. 12. (16 June 2005), pp. 4138-4152.
    by WM Rockey, AH Elcock
    posted to kinase by tjimenez on 2007-01-12 12:50:18 as ** along with 2 people BragilMassoud apostola
  • Protein kinase inhibition: different approaches to selective inhibitor design.
    Curr Drug Targets, Vol. 7, No. 11. (November 2006), pp. 1443-1454.
    by G Scapin
    posted to kinase by tjimenez on 2007-01-12 12:45:20 as **
  • Kinase conformations: a computational study of the effect of ligand binding.
    Protein Sci, Vol. 6, No. 11. (November 1997), pp. 2336-2343.
    by V Helms, JA McCammon
    posted to kinase by tjimenez on 2007-01-29 12:39:54 as **
  • Structure selection for protein kinase docking and virtual screening: homology models or crystal structures?
    Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 437-457.
    by WM Rockey, AH Elcock
    posted to models kinase homology by tjimenez on 2007-01-12 12:38:05 as **
  • Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism.
    Proc Natl Acad Sci U S A, Vol. 103, No. 47. (21 November 2006), pp. 17783-17788.
    by AP Kornev, NM Haste, SS Taylor, LF Eyck
    posted to kinase by tjimenez on 2007-01-18 09:53:36 as **
  • Sequence and structure classification of kinases.
    J Mol Biol, Vol. 320, No. 4. (19 July 2002), pp. 855-881.
    by S Cheek, H Zhang, NV Grishin
    posted to kinase by tjimenez on 2007-10-24 10:12:46 as **
  • A comprehensive update of the sequence and structure classification of kinases.
    BMC Struct Biol, Vol. 5, No. 1. (16 March 2005)
    by S Cheek, K Ginalski, H Zhang, NV Grishin
    posted to kinase by tjimenez on 2007-10-24 10:12:29 as ** along with 1 person and 2 groups barry structural_bioinformatics Bioinformatics
  • Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?
    Biochemistry, Vol. 42, No. 3. (28 January 2003), pp. 601-607.
    by JA Adams
    posted to kinase by tjimenez on 2007-01-16 10:46:48 as **
  • Kinase inhibitors: not just for kinases anymore.
    J Med Chem, Vol. 46, No. 8. (10 April 2003), pp. 1478-1483.
    by SL McGovern, BK Shoichet
    posted to kinase by tjimenez on 2007-01-12 17:04:54 as ** along with 1 person blackbart
  • Computational identification of proteins for selectivity assays.
    Proteins, Vol. 59, No. 3. (15 May 2005), pp. 434-443.
    by S Yoon, A Smellie, D Hartsough, A Filikov
    posted to kinase by tjimenez on 2007-01-12 17:03:19 as **
  • Elucidation of characteristic structural features of ligand binding sites of protein kinases: a neural network approach.
    J Chem Inf Model, Vol. 46, No. 5. (t 2006), pp. 2158-2166.
    by T Niwa
    posted to kinase by tjimenez on 2007-01-12 17:01:36 as **
  • Exploring sequence-structure relationships in the tyrosine kinome space: functional classification of the binding specificity mechanisms for cancer therapeutics.
    Bioinformatics (Oxford, England), Vol. 23, No. 15. (1 August 2007), pp. 1919-1926.
    by GM Verkhivker
    posted to kinase by tjimenez on 2008-04-17 09:26:18 as **
  • Rational design of inhibitors that bind to inactive kinase conformations.
    Nat Chem Biol, Vol. 2, No. 7. (July 2006), pp. 358-364.
    by Y Liu, NS Gray
    posted to kinase by tjimenez on 2007-01-12 16:56:18 as ** along with 1 person kentsis
  • Computational proteomics of biomolecular interactions in the sequence and structure space of the tyrosine kinome: Deciphering the molecular basis of the kinase inhibitors selectivity.
    Proteins (15 December 2006)
    by Gennady M M Verkhivker
    posted to kinase by tjimenez on 2007-01-12 16:52:06 as **
  • Structural biology in drug design: selective protein kinase inhibitors.
    Drug Discov Today, Vol. 7, No. 11. (1 June 2002), pp. 601-611.
    by G Scapin
    posted to kinase by tjimenez on 2007-01-12 16:45:23 as **
  • Chemical genetic approaches to kinase drug discovery.
    Curr Opin Drug Discov Devel, Vol. 8, No. 5. (September 2005), pp. 638-645.
    by SL Gallion, D Qian
    posted to kinase by tjimenez on 2007-01-12 16:31:18 as **
  • Kinomics-structural biology and chemogenomics of kinase inhibitors and targets.
    Biochim Biophys Acta, Vol. 1697, No. 1-2. (11 March 2004), pp. 243-257.
    by M Vieth, RE Higgs, DH Robertson, M Shapiro, EA Gragg, H Hemmerle
    posted to kinase by tjimenez on 2007-01-12 16:29:42 as **
  • Selectivity assessment of kinase inhibitors: strategies and challenges.
    Curr Opin Mol Ther, Vol. 7, No. 3. (June 2005), pp. 251-255.
    by Y Luo
    posted to kinase by tjimenez on 2007-01-12 16:27:15 as **
  • A priori inference of cross reactivity for drug-targeted kinases.
    J Med Chem, Vol. 49, No. 11. (1 June 2006), pp. 3092-3100.
    by A Fernandez, S Maddipati
    posted to kinase by tjimenez on 2007-01-12 16:26:48 as ** along with 2 people BragilMassoud kuhn
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