Thu, 21 Aug 2008 03:46:08 BST CiteULike: zwangs disease http://www.citeulike.org/user/zwang/tag/disease CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/zwang/article/2390472 <i>Proceedings of the National Academy of Sciences (8 February 2008), 0711977105.</i><br /><br />A method of inhibiting the expression of particular genes by using external guide sequences (EGSs) has been improved in its rapidity and specificity. Random EGSs that have 14-nt random sequences are used in the selection procedure for an EGS that attacks the mRNA for a gene in a particular location. A mixture of the random EGSs, the particular target RNA, and RNase P is used in the diagnostic procedure, which, after completion, is analyzed in a gel with suitable control lanes. Within a few hours, the procedure is complete. The action of EGSs designed by an older method is compared with EGSs designed by the random EGS method on mRNAs from two bacterial pathogens. 10.1073/pnas.0711977105 Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences Eirik Lundblad Gaoping Xiao Jae-Hyeong Ko Sidney Altman doi:10.1073/pnas.0711977105 Proceedings of the National Academy of Sciences (8 February 2008), 0711977105. 2008-02-17T10:55:53-00:00 2008 Proceedings of the National Academy of Sciences 0711977105 disease ecoli rna rnasep selection sequence http://www.citeulike.org/user/zwang/article/1813834 <i>Annual Review of Genomics and Human Genetics, Vol. 8, No. 1., 17.</i> Gene Duplication: A Drive for Phenotypic Diversity and Cause of Human Disease Annual Review of Genomics and Human Genetics, Vol. 8, No. 1., 17. 2007-10-24T03:08:48-00:00 Annual Review of Genomics and Human Genetics 8 1 17 disease diversity duplication evolution gene human phenotype http://www.citeulike.org/user/zwang/article/1302073 <i>Nature, Vol. 447, No. 7142. (17 May 2007), pp. 279-283.</i> Origins of major human infectious diseases Nathan Wolfe Claire Dunavan Jared Diamond doi:10.1038/nature05775 Nature, Vol. 447, No. 7142. (17 May 2007), pp. 279-283. 2007-05-17T12:42:57-00:00 2007 Nature 447 7142 279 283 disease human