Thu, 21 Aug 2008 07:21:40 BST CiteULike: zwangs Lappe http://www.citeulike.org/user/zwang/author/Lappe CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/zwang/article/2793797 <i>Proceedings of the National Academy of Sciences (12 May 2008), 0708078105.</i><br /><br />After the completion of the human and other genome projects it emerged that the number of genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our perception of their relative complexity. Here, we provide reliable evidence that the size of protein interaction networks in different organisms appears to correlate much better with their apparent biological complexity. We develop a stable and powerful, yet simple, statistical procedure to estimate the size of the whole network from subnet data. This approach is then applied to a range of eukaryotic organisms for which extensive protein interaction data have been collected and we estimate the number of interactions in humans to be approx650,000. We find that the human interaction network is one order of magnitude bigger than the Drosophila melanogaster interactome and approx3 times bigger than in Caenorhabditis elegans. 10.1073/pnas.0708078105 Estimating the size of the human interactome Michael Stumpf Thomas Thorne Eric de Silva Ronald Stewart Hyeong An Michael Lappe Carsten Wiuf doi:10.1073/pnas.0708078105 Proceedings of the National Academy of Sciences (12 May 2008), 0708078105. 2008-05-13T07:34:25-00:00 2008 Proceedings of the National Academy of Sciences 0708078105 genome-wide human interaction