Thu, 21 Aug 2008 09:38:23 BST CiteULike: zwangs Cavalli-Sforza http://www.citeulike.org/user/zwang/author/Cavalli-Sforza CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/zwang/article/2410507 <i>Science, Vol. 319, No. 5866. (22 February 2008), pp. 1100-1104.</i><br /><br />Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations of the Human Genome Diversity Panel at 650,000 common single-nucleotide polymorphism loci. Individual ancestry and population substructure were detectable with very high resolution. The relationship between haplotype heterozygosity and geography was consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa. In addition, we observed a pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions. This data set allows the most comprehensive characterization to date of human genetic variation. 10.1126/science.1153717 Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation Jun Li Devin Absher Hua Tang Audrey Southwick Amanda Casto Sohini Ramachandran Howard Cann Gregory Barsh Marcus Feldman Luigi Cavalli-Sforza Richard Myers doi:10.1126/science.1153717 Science, Vol. 319, No. 5866. (22 February 2008), pp. 1100-1104. 2008-02-22T08:51:45-00:00 2008 Science 319 5866 1100 1104 evolution genome-wide human