Thu, 21 Aug 2008 09:34:47 BST CiteULike: shivakmrs Gallarda http://www.citeulike.org/user/shivakmr/author/Gallarda CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/shivakmr/article/2658525 <i>Science, Vol. 320, No. 5873. (11 April 2008), pp. 233-236.</i><br /><br />Execution of motor behaviors relies on circuitries effectively integrating immediate sensory feedback to efferent pathways controlling muscle activity. It remains unclear how, during neuromuscular circuit assembly, sensory and motor projections become incorporated into tightly coordinated, yet functionally separate pathways. We report that, within axial nerves, establishment of discrete afferent and efferent pathways depends on coordinate signaling between coextending sensory and motor projections. These heterotypic axon-axon interactions require motor axonal EphA3/EphA4 receptor tyrosine kinases activated by cognate sensory axonal ephrin-A ligands. Genetic elimination of trans-axonal ephrin-A [->] EphA signaling in mice triggers drastic motor-sensory miswiring, culminating in functional efferents within proximal afferent pathways. Effective assembly of a key circuit underlying motor behaviors thus critically depends on trans-axonal signaling interactions resolving motor and sensory projections into discrete pathways. 10.1126/science.1153758 Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling Benjamin Gallarda Dario Bonanomi Daniel Muller Arthur Brown William Alaynick Shane Andrews Greg Lemke Samuel Pfaff Till Marquardt doi:10.1126/science.1153758 Science, Vol. 320, No. 5873. (11 April 2008), pp. 233-236. 2008-04-11T18:06:45-00:00 2008 Science 320 5873 233 236 brian general motor-control neural-organization nichola