Thu, 21 Aug 2008 04:52:06 BST CiteULike: raiyars Dietrich http://www.citeulike.org/user/raiyar/author/Dietrich CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/raiyar/article/2707822 <i>Médecine sciences : M/S, Vol. 23, No. 5. (May 2007), pp. 519-525.</i><br /><br />Mitochondrial disorders can not be ignored anymore in most medical areas. They include specific and widespread organ involvement, with tissue degeneration or tumor formation, being the target of numerous viruses, e.g. the HIV. Primary or secondary actors, mitochondrial dysfunctions are also supposedly playing a role in the ageing process. Despite the progresses made in the identification of their molecular bases, nearly all remains to be done as regards therapy. Research dealing with mitochondrial physiology and pathology has a long history in France and is thus not a surprise if four French teams, coming from these fundamental domains, are involved in the challenge to find ways to fight these diseases. The directions described are working tracks which promise to be long and full of pitfalls. Being original, they share a part of risk and uncertainty, but they are also with great potential with high stakes if considering the impact of these diseases. [Targeting allotopic material to the mitochondrial compartment: new tools for better understanding mitochondrial physiology and prospect for therapy] P Rustin H T Jacobs A Dietrich R N Lightowlers I Tarassov M Corral-Debrinski Médecine sciences : M/S, Vol. 23, No. 5. (May 2007), pp. 519-525. 2008-04-23T14:37:39-00:00 2007 Médecine sciences : M/S 0767-0974 23 5 519 525 allotopic mitochondria mitotarget projmt review http://www.citeulike.org/user/raiyar/article/1530884 <i>PNAS, Vol. 104, No. 31. (31 July 2007), pp. 12825-12830.</i><br /><br />We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, including growth at high temperature and deadly virulence in mouse models. Here we show that the approx12-Mb genome of YJM789 contains approx60,000 SNPs and approx6,000 indels with respect to the reference S288c genome, leading to protein polymorphisms with a few known cases of phenotypic changes. Several ORFs are found to be unique to YJM789, some of which might have been acquired through horizontal transfer. Localized regions of high polymorphism density are scattered over the genome, in some cases spanning multiple ORFs and in others concentrated within single genes. The sequence of YJM789 contains clues to pathogenicity and spurs the development of more powerful approaches to dissecting the genetic basis of complex hereditary traits. 10.1073/pnas.0701291104 Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789 Wu Wei John Mccusker Richard Hyman Ted Jones Ye Ning Zhiwei Cao Zhenglong Gu Dan Bruno Molly Miranda Michelle Nguyen Julie Wilhelmy Caridad Komp Raquel Tamse Xiaojing Wang Peilin Jia Philippe Luedi Peter Oefner Lior David Fred Dietrich Yixue Li Ronald Davis Lars Steinmetz doi:10.1073/pnas.0701291104 PNAS, Vol. 104, No. 31. (31 July 2007), pp. 12825-12830. 2007-08-02T15:14:27-00:00 2007 PNAS 104 31 12825 12830 bioinformatics genomics yeast yjm789