Thu, 21 Aug 2008 04:53:17 BST CiteULike: omalbams Chansky http://www.citeulike.org/user/omalbam/author/Chansky CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/omalbam/article/2323185 <i>Am J Physiol Endocrinol Metab, Vol. 284, No. 6. (1 June 2003), pp. E1112-1118.</i><br /><br />Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL2 and HDL3. It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipids and triacylglycerol. To determine how HDL-C and LDL-C particles are affected by testosterone administration to eugonadal men, testosterone was administered as a supraphysiological dose (600 mg/wk) for 3 wk to elderly, obese, eugonadal men before elective hip or knee surgery, and lipids were measured by routine methods and by density gradient ultracentrifugation. Hepatic lipase activity increased >60% above baseline levels, and HDL-C, HDL2, and HDL3 significantly declined in 3 wk. In addition, the LDL-C peak particle density and the amount of LDL-C significantly increased. Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL2, and HDL3 as well as increasing LDL particle density changes, all associated with increased cardiovascular risk. 10.1152/ajpendo.00524.2002 Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk Karen Herbst John Amory John Brunzell Howard Chansky William Bremner doi:10.1152/ajpendo.00524.2002 Am J Physiol Endocrinol Metab, Vol. 284, No. 6. (1 June 2003), pp. E1112-1118. 2008-02-02T15:11:24-00:00 2003 Am J Physiol Endocrinol Metab 284 6 E1112 1118 aging hplp physiology rct testosterone