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Xenobiotica

Articles from the last few issues of Xenobiotica © Taylor and Francis Ltd
  • Pharmacokinetics of 1,8-cineole, a dietary toxin, in the brushtail possum (Trichosurus vulpecula): Significance for feeding
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 903-922.
    by Mclean, , Boyle, , Brandon, , Davies, , Sorensen,
  • Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 923-942.
    by Mandlekar, , Rose, , Cornelius, , Sleczka, , Caporuscio, , Wang, , Marathe,
  • Roles of human CYP2A6 and rat CYP2B1 in the oxidation of (+)-fenchol by liver microsomes
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 943-953.
    by Miyazawa, , Gyoubu,
  • Identification and characterization of two chloramphenicol glucuronides from the in vitro glucuronidation of chloramphenicol in human liver microsomes
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 954-971.
    by Chen, , Howe, , Leduc, , Kerr, , Williams,
  • In vitro metabolism of a triclyclic alkaloid (M445526) in human liver microsomes and hepatocytes
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 972-985.
    by Mccormick, , Slamon, , Lenz, , Phillips, , King, , Mckillop, , Roberts,
  • Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: The effect of the expression of cytochrome b5 with recombinant P450 enzymes
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 986-999.
    by Emoto, , Iwasaki,
  • Studies of metabolism and disposition of potent human immunodeficiency virus (HIV) integrase inhibitors using 19F-NMR spectroscopy
    Xenobiotica, Vol. 37, No. 9. (September 2007), pp. 1000-1012.
    by Monteagudo, , Pesci, , Taliani, , Fiore, , Petrocchi, , Nizi, , Rowley, , Laufer, , Summa,
  • Effects of ertiprotafib on hepatic cytochrome P450 and peroxisomal enzymes in rats and dogs, and in rat and human primary hepatocytes
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 1-18.
    by Tong, , Chandrasekaran, , Jordan, , Markiewicz, , Li, , Xiang, , Shen, , Scatina,
  • Inhibition and recovery of maternal and foetal cholinesterase enzymes following fenitrothion administration in CD rats
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 19-29.
    by Sochaski, , Mcmanus, , Struve, , Wallace, , Dorman,
  • CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 30-43.
    by Uno, , Kumano, , Kito, , Nagata, , Kamataki, , Fujino,
  • Metabolism of [sup14/supC]-5-chloro-1,3-benzodioxol-4-amine in male Wistar-derived rats following intraperitoneal administration
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 44-58.
    by Athersuch, , Duckett, , Castro-Perez, , Rodgers, , Nicholson, , Wilson,
  • Stereoselective pharmacokinetics of oxybutynin and iN/i-desethyloxybutynin iin vitro/i and iin vivo/i
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 59-73.
    by Mizushima, , Takanaka, , Abe, , Fukazawa, , Ishizuka,
  • Pharmacokinetic study of darbepoetin alfa: Absorption, distribution, and excretion after a single intravenous and subcutaneous administration to rats
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 74-90.
    by Yoshioka, , Kato, , Shindo, , Mitsuoka, , Kitajima, -I, Ogata, , Misaizu,
  • Prediction of pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in humans using animal data
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 91-102.
    by Shibayama, , Matsushita, , Kurihara, , Hirota, , Ikeda,
  • Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations
    Xenobiotica, Vol. 37, No. 1. (January 2007), pp. 103-112.
    by Chen, , Li, , Yin, , Xu, , Ji, , Xiu, , Liu, , Ma,
  • Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1165-1177.
    by A Nekvindov, , Maaek, , A Veinlichov, , A Anzenbacherov, , Anzenbacher, , Zadek, , A Hol,
  • Glucuronidation in the chimpanzee (biPan troglodytes/i/b): Studies with acetaminophen, oestradiol and morphine
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1178-1190.
    by Wong1, , Grace, , Wright2, , Browning, , Grossman, , Bai3, , Christ4,
  • Ethnic differences in the distribution of iCYP3A5/i gene polymorphisms
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1191-1200.
    by Quaranta, , Chevalier, , Allorge, , Lo-Guidice, , Migot-Nabias, , Kenani, , Imbenotte, , Broly, , Lacarelle, , Lhermitte,
  • Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1201-1209.
    by Yamazaki, , Okayama, , Imai, , Guengerich, , Shimizu,
  • Marmoset iCYP/i3iA/i21, a model for human iCYP/i3iA/i4: Protein expression and functional characterization of the promoter
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1210-1226.
    by Koehler, , Ahsen, N Von, Schlumbohm, , Asif, , Goedtel-Armbrust, , Oellerich, , Wojnowski, , Armstrong,
  • Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR)aIaandaIaactivator, in mice, rats, dogs, and monkeys
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1227-1238.
    by Hosagrahara4, , Chandrasena5, , Chang, , Koplowitz, , Hariharan, , Cheng, , Humphreys, W Griffith
  • Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: Do adenosine Asub1/sub antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1239-1258.
    by Mustafa, , Venkatesh, , Pasha, , Mullangi, , Srinivas,
  • Metabolism and excretion of piperonyl butoxide in the rat
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1259-1272.
    by Byard, , Needham,
  • Renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in rabbits in comparison with meropenem
    Xenobiotica, Vol. 36, No. 12. (December 2006), pp. 1273-1287.
    by Shibayama, , Yamamura, , Matsushita, , Tokui, , Hirota, , Ikeda,
  • Expressed sequence tags (ESTs) and single nucleotide polymorphisms (SNPs): What large-scale sequencing projects can tell us about ADME
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 860-876.
    by Plant,
  • Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 877-901.
    by Ekins, , Bugrim, , Brovold, , Kirillov, , Nikolsky, , Rakhmatulin, , Sorokina, , Ryabov, , Serebryiskaya, , Melnikov, , Metz, , Nikolskaya,
    posted by 2 people GeneGo shikin
  • Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice iin vivo/i
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 902-937.
    by Slatter, , Cheng, , Cornwell, , De Souza, , Rockett, , Rushmore, , Hartley, , Evers, , He, , Dai, , Hu, , Caguyong, , Roberts, , Castle, , Ulrich,
  • Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 938-962.
    by Slatter, , Templeton, , Castle, , Kulkarni, , Rushmore, , Richards, , He, , Dai, , Cheng, , Caguyong, , Ulrich,
  • Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 963-988.
    by Bleasby, , Castle, , Roberts, , Cheng, , Bailey, , Sina, , Kulkarni, , Hafey, , Evers, , Johnson, , Ulrich, , Slatter,
  • ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 989-1012.
    by Finkelstein, , Lamba, , Assem, , Rengelshausen, , Yasuda, , Strom, , Schuetz,
  • Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drugadrug interactions
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 1013-1080.
    by Lee, , Ayanoglu, , Gong,
  • Tissue and species distribution of the glutathione pathway transcriptome
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 1081-1121.
    by Mattes, , Daniels, , Summan, , Xu, , Mendrick,
  • Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 1122-1139.
    by Hultin-Rosenberg, , Jagannathan, , Nilsson, , Matis, , Sjagren, , Huby, , Salter, , Tugwood,
  • Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 1140-1151.
    by Lim, , Currie, , Orphanides, , Moggs,
  • Nuclear receptors CAR and PXR in the regulation of hepatic metabolism
    Xenobiotica, Vol. 36, No. 10-11. (8220), pp. 1152-1163.
    by Tien, , Negishi,
  • Transesterification of p -hydroxybenzoate esters (parabens) by human intestinal (Caco-2) cells
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 739-749.
    by Lakeram, , Paine, , Lockley, , Sanders, , Pendlington, , Forbes,
  • Biotransformation and pharmacokinetics of the antiplasmodial naphthylisoquinoline alkaloid dioncophylline A
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 750-762.
    by Sieber, , Dekant, , Faber, , Bringmann,
  • Metabolism of N -substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 763-771.
    by Keizers, , Van Dijk, , De Graaf, , Van Vugt-Lussenburg, , Vermeulen, , Commandeur,
  • Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 772-792.
    by Gut, , Ojima, , Vaclavikova, , Simek, , Horsky, , Linhart, , Soucek, , Kondrova, , Kuznetsova, , Chen,
  • Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 793-806.
    by Barton, , Tang5, , Sey, , Stanko, , Murrell6, , Rockett7, , Dix,
  • Disposition and metabolism of almotriptan in rats, dogs and monkeys
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 807-823.
    by Aubets, , Cardenas, , Salva, , Jansat, , Martinez-Tobed, , Palacios,
  • Disposition of 2,2,4,4,5,5-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 824-837.
    by Sanders, , Lebetkin, , Chen, -J, Burka,
  • Influence of cholestyramine on the pharmacokinetics of rosiglitazone and its metabolite, desmethylrosiglitazone, after oral and intravenous dosing of rosiglitazone: Impact on oral bioavailability, absorption, and metabolic disposition in rats
    Xenobiotica, Vol. 36, No. 9. (September 2006), pp. 838-856.
    by Muzeeb, , Venkatesh, , Mullangi, , Srinivas,
  • In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S -transferase: Species differences and stereoselectivity
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 659-670.
    by Cannady, , Chien, , Jones, , Borel,
  • Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 671-683.
    by Emoto, , Murase, , Iwasaki,
  • CYP2A6 polymorphisms in Malays, Chinese and Indians
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 684-692.
    by Nurfadhlina, , Foong, , Teh, , Tan, , Zaki, S Mohd, Ismail,
  • Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 693-708.
    by Schmelzer, , Acikgoez, , Fruhauf, , Crome, , Klempnauer, , Christians, , Bader,
  • Metabolism of the recently encountered designer drug, methylone, in humans and rats
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 709-723.
    by Kamata, , Shima, , Zaitsu, , Kamata, , Miki, , Nishikawa, , Katagi, , Tsuchihashi,
  • Kinetics of paraquat in the isolated rat lung: Influence of sodium depletion
    Xenobiotica, Vol. 36, No. 8. (August 2006), pp. 724-737.
    by Dinis-Oliveira, , Valle, MJ De Jesus, Bastos, , Carvalho, , Sanchez Navarro,
  • Prediction of metabolic drug clearance in humans: In vitroin vivo extrapolation vs allometric scaling
    Xenobiotica, Vol. 36, No. 7. (July 2006), pp. 567-580.
    by Shiran, , Proctor, , Howgate, , Rowland-Yeo, , Tucker, , Rostami-Hodjegan,
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