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Laboratory Investigation

Articles from the last few issues of Laboratory Investigation © Nature Publishing Group
  • Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues
    Laboratory Investigation, Vol. aop, No. current.
    by Fausto J Rodriguez, Jeffrey D Gamez, Julie A Vrana, Jason D Theis, Caterina Giannini, Bernd W Scheithauer, Joseph E Parisi, Claudia F Lucchinetti, William W Pendlebury, Robert H Bergen, Ahmet Dogan
  • Smad3 knockout mice exhibit impaired intestinal mucosal healing
    Laboratory Investigation, Vol. aop, No. current.
    by Cheri R Owen, Lisi Yuan, Marc D Basson
  • Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
    Laboratory Investigation, Vol. aop, No. current.
    by Christopher R Weber, Sam C Nalle, Maria Tretiakova, David T Rubin, Jerrold R Turner
  • Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice
    Laboratory Investigation, Vol. aop, No. current.
    by Kwangsuk Ko, Heping Yang, Mazen Noureddin, Ainhoa Iglesia-Ara, Meng Xia, Conrad Wagner, Zigmund Luka, José M Mato, Shelly C Lu
  • Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
    Laboratory Investigation, Vol. aop, No. current.
    by Seth Guller, Catalin S Buhimschi, Yula Y Ma, Se, Liubin Yang, Edward Kuczynski, Eduardo Zambrano, Charles J Lockwood, Irina A Buhimschi
  • Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model
    Laboratory Investigation, Vol. aop, No. current.
    by Chiou-Feng Lin, Shu-Wen Wan, Mei-Chun Chen, Shin-Chao Lin, Chu-Chen Cheng, Shu-Chen Chiu, Yu-Ling Hsiao, Huan-Yao Lei, Hsiao-Sheng Liu, Trai-Ming Yeh, Yee-Shin Lin
  • Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction
    Laboratory Investigation, Vol. aop, No. current.
    by Pinpat Tripatara, Nimesh SA Patel, Massimo Collino, Margherita Gallicchio, Julius Kieswich, Sara Castiglia, Elisa Benetti, Keith N Stewart, Paul AJ Brown, Mohammed M Yaqoob, Roberto Fantozzi, Christoph Thiemermann
  • The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    Laboratory Investigation, Vol. aop, No. current.
    by Weihua Xu, Claus Hellerbrand, Ulrike A Köhler, Philippe Bugnon, Yuet-Wai Kan, Sabine Werner, Tobias A Beyer
  • Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays
    Laboratory Investigation, Vol. aop, No. current.
    by Thorsten Wiech, Elisabeth Nikolopoulos, Roland Weis, Rupert Langer, Kilian Bartholomé, Jens Timmer, Axel K Walch, Heinz Höfler, Martin Werner
  • Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury
    Laboratory Investigation, Vol. aop, No. current.
    by Erawan Borkham-Kamphorst, Evgenia Kovalenko, Claudia RC van Roeyen, Nikolaus Gassler, Michael Bomble, Tammo Ostendorf, Jürgen Floege, Axel M Gressner, Ralf Weiskirchen
  • Characterization of bacterial DNA binding to human neutrophil surface
    Laboratory Investigation, Vol. aop, No. current.
    by Juan, Maria L Gabelloni, María E Alvarez, Mónica E Vermeulen, Daniela M Russo, Ángeles Zorreguieta, Jorge R Geffner, Analía S Trevani
  • Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway
    Laboratory Investigation, Vol. aop, No. current.
    by Lynda Aoudjehane, Alcindo Pissaia, Olivier Scatton, Philippe Podevin, Pierre-Philippe Massault, Sandrine Chouzenoux, Olivier Soubrane, Yvon Calmus, Filomena Conti
  • Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells
    Laboratory Investigation, Vol. aop, No. current.
    by Harriet M Kluger, Summar F Siddiqui, Cesar Angeletti, Mario Sznol, William K Kelly, Annette M Molinaro, Robert L Camp
  • The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy
    Laboratory Investigation, Vol. aop, No. current.
    by Waichi Sato, Tomoki Kosugi, Li Zhang, Carlos A Roncal, Marcelo Heinig, Martha Campbell-Thompson, Yukio Yuzawa, Mark A Atkinson, Maria B Grant, Byron P Croker, Takahiko Nakagawa
    posted by 1 person jyuh
  • Intrafollicular location of marginal zone/CD1dhi B cells is associated with autoimmune pathology in a mouse model of lupus
    Laboratory Investigation, Vol. aop, No. current.
    by Biyan Duan, Haitao Niu, Zhiwei Xu, Arlene H Sharpe, Byron P Croker, Eric S Sobel, Laurence Morel
  • Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury
    Laboratory Investigation, Vol. aop, No. current.
    by Manuela Gatto, Veronica Drudi-Metalli, Alessia Torrice, Gianfranco Alpini, Alfredo Cantafora, Ida Blotta, Domenico Alvaro
  • Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland
    Laboratory Investigation, Vol. aop, No. current.
    by Charles E Wood, Joy M Hester, Susan E Appt, Kim R Geisinger, Mark J Cline
  • Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas
    Laboratory Investigation, Vol. aop, No. current.
    by Jingxin Qiu, Lingbao Ai, Cheppail Ramachandran, Bing Yao, Suhasni Gopalakrishnan, Robert C Fields, Amber L Delmas, Lisa M Dyer, Steven J Melnick, Anthony T Yachnis, Philip H Schwartz, Howard A Fine, Kevin D Brown, Keith D Robertson
  • The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytes
    Laboratory Investigation, Vol. aop, No. current.
    by Pichili VB Reddy, Kakulavarapu, Michael D Norenberg
  • The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
    Laboratory Investigation, Vol. aop, No. current.
    by Motoko Sasaki, Hiroko Ikeda, Keita Itatsu, Junpei Yamaguchi, Seiko Sawada, Hiroshi Minato, Tetsuo Ohta, Yasuni Nakanuma
  • Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    Laboratory Investigation, Vol. aop, No. current.
    by Pallavi B Limaye, Gabriela Alarcón, Andrew L Walls, Michael A Nalesnik, George K Michalopoulos, Anthony J Demetris, Erin R Ochoa
  • Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation
    Laboratory Investigation, Vol. aop, No. current.
    by Mei-Yu Hsu, Sherry A Rovinsky, Chiou-Yan Lai, Shadi Qasem, Xiaoming Liu, Joan How, John F Engelhardt, George F Murphy
  • Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas
    Laboratory Investigation, Vol. aop, No. current.
    by Kyeung M Joo, Shi Y Kim, Xun Jin, Sang Y Song, Doo-Sik Kong, Jung-Ii Lee, Ji W Jeon, Mi H Kim, Bong G Kang, Yong Jung, Juyoun Jin, Seung-Chyul Hong, Woong-Yang Park, Dong-Sup Lee, Hyunggee Kim, Do-Hyun Nam
  • Expression of galectin-3 in the tumor immune response in colon cancer
    Laboratory Investigation, Vol. aop, No. current.
    by Patrick Dumont, Alix Berton, Nathalie Nagy, Flavienne Sandras, Sandrine Tinton, Pieter Demetter, Françoise Mascart, Abdelmounaaïm Allaoui, Christine Decaestecker, Isabelle Salmon
  • Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
    Laboratory Investigation, Vol. aop, No. current.
    by Annamaria Venturi, Fabrizio D Piaz, Catia Giovannini, Laura Gramantieri, Pasquale Chieco, Luigi Bolondi
  • Stat4 suppresses the proliferation of connective tissue-type mast cells
    Laboratory Investigation, Vol. aop, No. current.
    by Tatsuki R Kataoka, Yasuko Nishizawa
  • Autoantibodies and neurodegeneration in multiple sclerosis
    Laboratory Investigation, Vol. aop, No. current.
    by Tamara Vyshkina, Bernadette Kalman
  • Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
    Laboratory Investigation, Vol. aop, No. current.
    by Niccola Funel, Elisa Giovannetti, Marco Del Chiaro, Valentina Mey, Luca E Pollina, Sara Nannizzi, Ugo Boggi, Simona Ricciardi, Mario Del Tacca, Generoso Bevilacqua, Franco Mosca, Romano Danesi, Daniela Campani
  • Cellular origins of adult human islet in vitro dedifferentiation
    Laboratory Investigation, Vol. aop, No. current.
    by Stephen C Hanley, Amélie Pilotte, Bernard Massie, Lawrence Rosenberg
  • Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells
    Laboratory Investigation, Vol. aop, No. current.
    by Hideki Kato, Junji Ishida, Katsumasa Nagano, Kaori Honjo, Takeshi Sugaya, Norifumi Takeda, Fumihiro Sugiyama, Ken-Ichi Yagami, Toshiro Fujita, Masaomi Nangaku, Akiyoshi Fukamizu
  • Modeling formalin fixation and histological processing with ribonuclease A: effects of ethanol dehydration on reversal of formaldehyde cross-links
    Laboratory Investigation, Vol. aop, No. current.
    by Carol B Fowler, Timothy J O'Leary, Jeffrey T Mason
    posted by 1 person brianb
  • Role of the life span determinant P66shcA in ethanol-induced liver damage
    Laboratory Investigation, Vol. aop, No. current.
    by Osvaldo R Koch, Salvatore Fusco, Sofia C Ranieri, Giuseppe Maulucci, Paola Palozza, Luigi M Larocca, Amerys AM Cravero, Stella M Farre', Marco De Spirito, Tommaso Galeotti, Giovambattista Pani
  • Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion
    Laboratory Investigation, Vol. aop, No. current.
    by Pawan Kumar, Yu Ning, Peter J Polverini
  • Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein
    Laboratory Investigation, Vol. aop, No. current.
    by Mayumi Kawada, Chun-Chuan Chen, Atsuko Arihiro, Katsuya Nagatani, Takeshi Watanabe, Emiko Mizoguchi
  • Helicobacter pylori invades the gastric mucosa and translocates to the gastric lymph nodes
    Laboratory Investigation, Vol. aop, No. current.
    by Takashi Ito, Daisuke Kobayashi, Keisuke Uchida, Tamiko Takemura, Sakae Nagaoka, Intetsu Kobayashi, Tetsuji Yokoyama, Ikuo Ishige, Yuki Ishige, Noriko Ishida, Asuka Furukawa, Hiroe Muraoka, Satoshi Ikeda, Masaki Sekine, Noboru Ando, Yoshimi Suzuki, Tetsuo Yamada, Takashige Suzuki, Yoshinobu Eishi
  • Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection
    Laboratory Investigation, Vol. aop, No. current.
    by Li Li, Isao Kosugi, Gui-Ping Han, Hideya Kawasaki, Yoshifumi Arai, Tamotsu Takeshita, Yoshihiro Tsutsui
  • The origins of bladder cancer
    Laboratory Investigation, Vol. aop, No. current.
    by James M Crawford
  • Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy
    Laboratory Investigation, Vol. aop, No. current.
    by Tadeusz Majewski, Sangkyou Lee, Joon Jeong, Dong-Sup Yoon, Andrzej Kram, Mi-Sook Kim, Tomasz Tuziak, Jolanta Bondaruk, Sooyong Lee, Weon-Seo Park, Kuang S Tang, Woonbok Chung, Lanlan Shen, Saira S Ahmed, Dennis A Johnston, Barton H Grossman, Colin P Dinney, Jain-Hua Zhou, Alan R Harris, Carrie Snyder, Slawomir Filipek, Steven A Narod, Patrice Watson, Henry T Lynch, Adi Gazdar, Menashe Bar-Eli, Xifeng F Wu, David J Mcconkey, Keith Baggerly, Jean-Pierre Issa, William F Benedict, Steven E Scherer, Bogdan Czerniak
    posted by 1 person jyuh
  • Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats
    Laboratory Investigation, Vol. aop, No. current.
    by Olga Ohayon, Nidal Mawasi, Anna Pevzner, Ana Tryvitz, Tsvia Gildor, Mark Pines, Marcos Rojkind, Melia Paizi, Gadi Spira
  • The acute cutaneous inflammatory response is attenuated in Slug-knockout mice
    Laboratory Investigation, Vol. aop, No. current.
    by Kimberly M Newkirk, Jason F Duncan, Erin M Brannick, Heather L Chandler, Allison E Parent, Donna F Kusewitt
  • Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis
    Laboratory Investigation, Vol. aop, No. current.
    by Ichiro Moriyama, Shunji Ishihara, Azharul, Monowar MD Aziz, Yoshiyuki Mishima, Naoki Oshima, Chikara Kadota, Yasunori Kadowaki, Yuji Amano, Yoshikazu Kinoshita
  • Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
    Laboratory Investigation, Vol. aop, No. current.
    by Maria van der Sluis, Janneke Bouma, Audrey Vincent, Anna Velcich, Kermit L Carraway, Hans A Büller, Alexandra WC Einerhand, Johannes B van Goudoever, Isabelle Van Seuningen, Ingrid B Renes
  • Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat
    Laboratory Investigation, Vol. aop, No. current.
    by Adrienne S Mccampbell, Cheryl L Walker, Russell R Broaddus, Jennifer D Cook, Peter JA Davies
  • Everything you wanted to know about small RNA but were afraid to ask
    Laboratory Investigation, Vol. aop, No. current.
    by Scott D Boyd
    posted by 5 people microRNA heliopais balicea GustavoLacerda bootsy
  • Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line
    Laboratory Investigation, Vol. aop, No. current.
    by Manisha Bajpai, Jianying Liu, Xin Geng, Rhonda F Souza, Peter S Amenta, Kiron M Das
  • Regulation of scar formation by vascular endothelial growth factor
    Laboratory Investigation, Vol. aop, No. current.
    by Traci A Wilgus, Ahalia M Ferreira, Tatiana M Oberyszyn, Valerie K Bergdall, Luisa A Dipietro
  • The fibromatosis signature defines a robust stromal response in breast carcinoma
    Laboratory Investigation, Vol. aop, No. current.
    by Andrew H Beck, Inigo Espinosa, Blake C Gilks, Matt van de Rijn, Robert B West
    posted by 1 person andrewhbeck
  • Diabetic eNOS knockout mice develop distinct macro- and microvascular complications
    Laboratory Investigation, Vol. aop, No. current.
    by Sumathy Mohan, Robert L Reddick, Nicolas Musi, Diane A Horn, Bo Yan, Thomas J Prihoda, Mohan Natarajan, Sherry L Abboud-Werner
    posted by 1 person jyuh
  • The cancer stem cell hypothesis: in search of definitions, markers, and relevance
    Laboratory Investigation, Vol. aop, No. current.
    by Michail Shipitsin, Kornelia Polyak
  • The CD4+CD26− T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile
    Laboratory Investigation, Vol. aop, No. current.
    by Yue Ma, Lydia Visser, Tjasso Blokzijl, Geert Harms, Çiǧdem Atayar, Sibrand Poppema, Anke van den Berg
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