Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease.

@article{citeulike:1996891, abstract = {Studies suggest motor deficit asymmetry may help predict the pattern of cognitive impairment in individuals with Parkinson disease (PD). We tested this hypothesis using a highly validated and sensitive spatial memory task, spatial delayed response (SDR), and clinical and neuroimaging measures of PD asymmetry. We predicted SDR performance would be more impaired by PD-related changes in the right side of the brain than in the left. PD (n=35) and control (n=28) participants performed the SDR task. PD participants either had worse motor deficits on the right (RPD) or left (LPD) side of the body. Some participants also had magnetic resonance imaging for measurement of their substantia nigra (SN) volumes. The LPD group performed worse on the SDR task than the RPD and control groups. Right SN volume accounted for a unique and significant portion of the variance in SDR error, with smaller volume predicting poorer performance. In conclusion, left motor dysfunction and smaller right SN volume are associated with poorer spatial memory.}, address = {Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.}, author = {Foster, Erin R R. and Black, Kevin J J. and Antenor-Dorsey, Jo Ann V A. and Perlmutter, Joel S S. and Hershey, Tamara }, citeulike-article-id = {1996891}, doi = {http://dx.doi.org/10.1016/j.bandc.2007.10.002}, issn = {0278-2626}, journal = {Brain Cogn}, keywords = {nichola, parkinsons}, month = {November}, posted-at = {2007-12-13 13:55:56}, priority = {2}, title = {Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease.}, url = {http://dx.doi.org/10.1016/j.bandc.2007.10.002}, year = {2007} }

TY - JOUR ID - citeulike:1996891 L3 - citeulike-article-id:1996891 TI - Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. JF - Brain Cogn AD - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. SN - 0278-2626 N2 - Studies suggest motor deficit asymmetry may help predict the pattern of cognitive impairment in individuals with Parkinson disease (PD). We tested this hypothesis using a highly validated and sensitive spatial memory task, spatial delayed response (SDR), and clinical and neuroimaging measures of PD asymmetry. We predicted SDR performance would be more impaired by PD-related changes in the right side of the brain than in the left. PD (n=35) and control (n=28) participants performed the SDR task. PD participants either had worse motor deficits on the right (RPD) or left (LPD) side of the body. Some participants also had magnetic resonance imaging for measurement of their substantia nigra (SN) volumes. The LPD group performed worse on the SDR task than the RPD and control groups. Right SN volume accounted for a unique and significant portion of the variance in SDR error, with smaller volume predicting poorer performance. In conclusion, left motor dysfunction and smaller right SN volume are associated with poorer spatial memory. KW - nichola KW - parkinsons AU - Foster, Erin R AU - Black, Kevin J AU - Antenor-Dorsey, Jo Ann V AU - Perlmutter, Joel S AU - Hershey, Tamara PY - 2007/11/15/ UR - http://dx.doi.org/10.1016/j.bandc.2007.10.002 ER -