Elaboration of PLLA-based superparamagnetic nanoparticles: Characterization, magnetic behaviour study and in vitro relaxivity evaluation

@article{citeulike:2295232, abstract = {Oleic acid-coated magnetite has been encapsulated in biocompatible magnetic nanoparticles (MNP) by a simple emulsion evaporation method. The different parameters influencing the particles size were studied. Between these parameters, the stirring speed and the polymer concentration were found to influence positively or negatively, respectively, the MNP size which varied between 320 and 1500 nm. The magnetite encapsulation efficacy was about than 90\% yielding a high magnetite loading of up to 30\% (w/w). X-ray diffraction showed that magnetite crystalline pattern was not modified after emulsification and solvent evaporation. The X-ray photoelectron spectroscopy (XPS) results indicated the presence of less than 0.1\% of iron atoms at the nanoparticles surface. Vibration simple magnetometer (VSM) showed a superparamagnetic behaviour of the MNP and a saturation magnetization increasing with the increased magnetite amount used in formulation. Moreover, T1 and T2 relaxivities of MNP (4.7 T, 20 [degree sign]C) were 1.7 +/- 0.1 and 228.3 +/- 13.1 s-1 mM-1, respectively, rendering them in the same category of known negative contrast agents which shorten the T2 relaxation time. Therefore, by using an appropriate anticancer drug in their formulation, these magnetic nanoparticles can present a promising mean for simultaneous tumor imaging, drug delivery and real time monitoring of therapeutic effect.}, author = {Hamoudeh, Misara and Faraj, Achraf A. and Canet-Soulas, Emmanuelle and Bessueille, Francois and Leonard, Didier and Fessi, Hatem }, citeulike-article-id = {2295232}, doi = {http://dx.doi.org/10.1016/j.ijpharm.2007.01.023}, journal = {International Journal of Pharmaceutics}, keywords = {magnetic, nanoparticles, polylactide}, month = {June}, number = {1-2}, pages = {248--257}, posted-at = {2008-01-27 18:47:49}, priority = {2}, title = {Elaboration of PLLA-based superparamagnetic nanoparticles: Characterization, magnetic behaviour study and in vitro relaxivity evaluation}, url = {http://dx.doi.org/10.1016/j.ijpharm.2007.01.023}, volume = {338}, year = {2007} }

TY - JOUR ID - citeulike:2295232 L3 - citeulike-article-id:2295232 N2 - Oleic acid-coated magnetite has been encapsulated in biocompatible magnetic nanoparticles (MNP) by a simple emulsion evaporation method. The different parameters influencing the particles size were studied. Between these parameters, the stirring speed and the polymer concentration were found to influence positively or negatively, respectively, the MNP size which varied between 320 and 1500 nm. The magnetite encapsulation efficacy was about than 90% yielding a high magnetite loading of up to 30% (w/w). X-ray diffraction showed that magnetite crystalline pattern was not modified after emulsification and solvent evaporation. The X-ray photoelectron spectroscopy (XPS) results indicated the presence of less than 0.1% of iron atoms at the nanoparticles surface. Vibration simple magnetometer (VSM) showed a superparamagnetic behaviour of the MNP and a saturation magnetization increasing with the increased magnetite amount used in formulation. Moreover, T1 and T2 relaxivities of MNP (4.7 T, 20 [degree sign]C) were 1.7 +/- 0.1 and 228.3 +/- 13.1 s-1 mM-1, respectively, rendering them in the same category of known negative contrast agents which shorten the T2 relaxation time. Therefore, by using an appropriate anticancer drug in their formulation, these magnetic nanoparticles can present a promising mean for simultaneous tumor imaging, drug delivery and real time monitoring of therapeutic effect. IS - 1-2 JF - International Journal of Pharmaceutics EP - 257 TI - Elaboration of PLLA-based superparamagnetic nanoparticles: Characterization, magnetic behaviour study and in vitro relaxivity evaluation VL - 338 SP - 248 KW - magnetic KW - nanoparticles KW - polylactide AU - Hamoudeh, Misara AU - Faraj, Achraf AU - Canet-Soulas, Emmanuelle AU - Bessueille, Francois AU - Leonard, Didier AU - Fessi, Hatem PY - 2007/06/29/ UR - http://dx.doi.org/10.1016/j.ijpharm.2007.01.023 ER -