Attenuation of sarcopenia by dietary restriction in rhesus monkeys.

@article{citeulike:2960513, abstract = {Sarcopenia, the loss of muscle mass with normal aging, devastates quality of life-and related healthcare expenditures are enormous. The prevention or attenuation of sarcopenia would be an important medical advance. Dietary restriction (DR) is the only dietary intervention that consistently extends median and maximum life span, as well as health span in rodents. Evidence suggests that DR will have a similar effect in primates. Furthermore, DR opposes sarcopenia in rodents. We tested the hypothesis that DR will reduce age-related sarcopenia in a nonhuman primate. Thirty adult male rhesus monkeys, half fed a normal calorie intake and half reduced by 30\% in caloric intake, were examined over 17 years for changes in dual-energy X-ray absorptiometry-estimated skeletal muscle mass. Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model.}, address = {Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct., Madison, WI 53715. rcolman@primate.wisc.edu.}, author = {Colman, R. J. and Beasley, T. M. and Allison, D. B. and Weindruch, R. }, citeulike-article-id = {2960513}, issn = {1079-5006}, journal = {The journals of gerontology. Series A, Biological sciences and medical sciences}, month = {June}, number = {6}, pages = {556--559}, posted-at = {2008-07-03 21:46:20}, priority = {2}, title = {Attenuation of sarcopenia by dietary restriction in rhesus monkeys.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18559628}, volume = {63}, year = {2008} }

TY - JOUR ID - citeulike:2960513 L3 - citeulike-article-id:2960513 N2 - Sarcopenia, the loss of muscle mass with normal aging, devastates quality of life-and related healthcare expenditures are enormous. The prevention or attenuation of sarcopenia would be an important medical advance. Dietary restriction (DR) is the only dietary intervention that consistently extends median and maximum life span, as well as health span in rodents. Evidence suggests that DR will have a similar effect in primates. Furthermore, DR opposes sarcopenia in rodents. We tested the hypothesis that DR will reduce age-related sarcopenia in a nonhuman primate. Thirty adult male rhesus monkeys, half fed a normal calorie intake and half reduced by 30% in caloric intake, were examined over 17 years for changes in dual-energy X-ray absorptiometry-estimated skeletal muscle mass. Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model. IS - 6 JF - The journals of gerontology. Series A, Biological sciences and medical sciences SN - 1079-5006 AD - Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct., Madison, WI 53715. rcolman@primate.wisc.edu. EP - 559 TI - Attenuation of sarcopenia by dietary restriction in rhesus monkeys. VL - 63 SP - 556 AU - Colman, RJ AU - Beasley, TM AU - Allison, DB AU - Weindruch, R PY - 2008/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/18559628 ER -