Nonequilibrium Mechanics of Active Cytoskeletal Networks

@article{Mizuno:2007, abstract = {Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate{\^a}€“dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation.}, annote = {Nonequilibrium Mechanics of Active Cytoskeletal Networks}, author = {Mizuno, D. and Tardin, C. and Schmidt, C. F. and Mackintosh, F. C. }, citeulike-article-id = {1331912}, journal = {Science}, keywords = {cellular\_mechanics}, number = {5810}, pages = {370--3}, posted-at = {2007-05-25 14:36:05}, priority = {0}, title = {Nonequilibrium Mechanics of Active Cytoskeletal Networks}, url = {http://dx.doi.org/10.1126/science.1134404}, volume = {315}, year = {2007} }

TY - JOUR ID - Mizuno:2007 L3 - citeulike-article-id:1331912 N2 - Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, actin filaments, and cross-linkers. In this system, stresses arising from motor activity controlled the cytoskeletal network mechanics, increasing stiffness by a factor of nearly 100 and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate{\^a}€“dependent manner. We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation. IS - 5810 JF - Science EP - 3 TI - Nonequilibrium Mechanics of Active Cytoskeletal Networks VL - 315 SP - 370 KW - cellular_mechanics AU - Mizuno, D AU - Tardin, C AU - Schmidt, CF AU - Mackintosh, FC PY - 2007/// UR - http://dx.doi.org/10.1126/science.1134404 ER -