Common kibra alleles are associated with human memory performance.

by: A Papassotiropoulos, DA Stephan, MJ Huentelman, FJ Hoerndli, DW Craig, JV Pearson, KD Huynh, F Brunner, J Corneveaux, D Osborne, MA Wollmer, A Aerni, D Coluccia, J Hänggi, CR Mondadori, A Buchmann, EM Reiman, RJ Caselli, K Henke, DJ de Quervain

Science, Vol. 314, No. 5798. (20 October 2006), pp. 475-478.

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Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.

@article{citeulike:910352, abstract = {Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.}, address = {Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland.}, author = {Papassotiropoulos, A. and Stephan, D. A. and Huentelman, M. J. and Hoerndli, F. J. and Craig, D. W. and Pearson, J. V. and Huynh, K. D. and Brunner, F. and Corneveaux, J. and Osborne, D. and Wollmer, M. A. and Aerni, A. and Coluccia, D. and H\"{a}nggi, J. and Mondadori, C. R. and Buchmann, A. and Reiman, E. M. and Caselli, R. J. and Henke, K. and de Quervain, D. J. }, citeulike-article-id = {910352}, doi = {http://dx.doi.org/10.1126/science.1129837}, issn = {1095-9203}, journal = {Science}, keywords = {snp}, month = {October}, number = {5798}, pages = {475--478}, posted-at = {2006-10-23 18:52:03}, priority = {4}, title = {Common kibra alleles are associated with human memory performance.}, url = {http://dx.doi.org/10.1126/science.1129837}, volume = {314}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:910352 L3 - citeulike-article-id:910352 N2 - Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory. IS - 5798 JF - Science SN - 1095-9203 AD - Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland. EP - 478 TI - Common kibra alleles are associated with human memory performance. VL - 314 SP - 475 KW - snp AU - Papassotiropoulos, A AU - Stephan, DA AU - Huentelman, MJ AU - Hoerndli, FJ AU - Craig, DW AU - Pearson, JV AU - Huynh, KD AU - Brunner, F AU - Corneveaux, J AU - Osborne, D AU - Wollmer, MA AU - Aerni, A AU - Coluccia, D AU - Hänggi, J AU - Mondadori, CR AU - Buchmann, A AU - Reiman, EM AU - Caselli, RJ AU - Henke, K AU - de Quervain, DJ PY - 2006/10/20/ UR - http://dx.doi.org/10.1126/science.1129837 ER -

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